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Obes Facts. 2017;10(3):273-283. doi: 10.1159/000471881. Epub 2017 Jun 10.

Neonatal Vitamin D Levels in Relation to Risk of Overweight at 7 Years in the Danish D-Tect Case-Cohort Study.

Author information

1
Department of Clinical Epidemiology (formerly Institute of Preventive Medicine), Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Denmark.

Abstract

BACKGROUND:

Vitamin D level in pregnancy may be associated with risk of overweight in the offspring later in life.

METHODS:

In a case-cohort study based on Danish biobanks and registers we examined the association between 25-hydroxy-vitamin D (25(OH)D) level at birth and overweight at 7 years. Cases of overweight (n = 871) were randomly selected among 7-year-old children from the Copenhagen School Health Records Register (CSHRR) with a BMI above the 90th percentile. The cohort (n = 1,311) was a random sample selected among all Danish children born during the same period. Neonatal 25(OH)D was measured in dried blood spots.

RESULTS:

25(OH)D3 exhibited the expected seasonal variation. Median level of 25(OH)D3 was 20.6 (11.9-33.3) nmol/l in the overweight group and 23.4 (13.5-34.3) nmol/l in the cohort. We found no association between neonatal 25(OH)D3 level and risk of overweight at age 7 years, neither in the crude model (OR (CI) 1.00 (0.99; 1.00)) nor in a model adjusted for maternal ethnicity, educational level, civil status, parity, season and year of birth, and offspring ponderal index (OR (CI) 1.00 (0.99; 1.01)).

CONCLUSION:

Risk of overweight at 7 years of age was not associated with vitamin D level at birth.

KEYWORDS:

BMI; Case-cohort study; Childhood overweight; Dried blood spots; Epidemiology; Vitamin D, pregnancy

PMID:
28601865
PMCID:
PMC5644932
DOI:
10.1159/000471881
[Indexed for MEDLINE]
Free PMC Article

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