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Vision Res. 2017 Oct;139:191-203. doi: 10.1016/j.visres.2017.05.006. Epub 2017 Jun 21.

OCT angiography and visible-light OCT in diabetic retinopathy.

Author information

1
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA. Electronic address: nesperpl@gmail.com.
2
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA; Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. Electronic address: briansoetikno@gmail.com.
3
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA; Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA. Electronic address: hfzhang@northwestern.edu.
4
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA. Electronic address: afawzimd@gmail.com.

Abstract

In recent years, advances in optical coherence tomography (OCT) techniques have increased our understanding of diabetic retinopathy, an important microvascular complication of diabetes. OCT angiography is a non-invasive method that visualizes the retinal vasculature by detecting motion contrast from flowing blood. Visible-light OCT shows promise as a novel technique for quantifying retinal hypoxia by measuring the retinal oxygen delivery and metabolic rates. In this article, we discuss recent insights provided by these techniques into the vascular pathophysiology of diabetic retinopathy. The next milestones for these modalities are large multicenter studies to establish consensus on the most reliable and consistent outcome parameters to study diabetic retinopathy.

KEYWORDS:

Diabetic retinopathy; Imaging; OCT; OCT angiography; Retina; Visible-light OCT

PMID:
28601429
PMCID:
PMC5723235
DOI:
10.1016/j.visres.2017.05.006
[Indexed for MEDLINE]
Free PMC Article

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