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Clin Nutr. 2018 Feb;37(1):72-77. doi: 10.1016/j.clnu.2017.05.015. Epub 2017 May 19.

Omega 3 fatty acids in cardiovascular disease risk factors: An updated systematic review of randomised clinical trials.

Author information

1
Department of Biochemistry and Molecular Biology Molecular II, Institute of Nutrition and Food Technology, Biomedical Research Centre, University of Granada, Granada, Spain.
2
Department of Biochemistry and Molecular Biology Molecular II, Institute of Nutrition and Food Technology, Biomedical Research Centre, University of Granada, Granada, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, CIBEROBN, Madrid, Spain. Electronic address: agil@ugr.es.

Abstract

Several studies and reviews regarding the supplementation of omega-3 LC-PUFAs have been developed during the last years. Indeed, the evidence states that high doses omega-3 LC-PUFAs produce a small but significant decrease in blood pressure in older and hypertensive subjects. Due to the increasing interest in the benefits of LC-PUFAs, we aimed to evaluate the scientific evidence provided in the past five years (2012-2016) on the effects of the intake of omega-3 LC-PUFAs on cardiovascular risk factors such as inflammation and oxidative stress, through a systematic review in PubMed database. Twenty-eight articles were related to cardiovascular disease (CVD) and are included in this systematic review. The studies included healthy subjects and CVD patients; we included the number of subjects, type of study, type and doses of omega-3 LC-PUFAs, primary outcomes, and results. The use of omega-3 LC-PUFAs for ameliorating CVD risk factors can be recommended. However, the administration of omega-3 does not seem to show any benefit for the management of CVD or associated complications.

KEYWORDS:

Cardiovascular disease risk factors; Omega-3; Systematic review

PMID:
28601400
DOI:
10.1016/j.clnu.2017.05.015

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