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J Neuroimmunol. 2017 Aug 15;309:38-40. doi: 10.1016/j.jneuroim.2017.05.009. Epub 2017 May 17.

Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder associated with esophageal cancer.

Author information

1
Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: t-kon@umin.ac.jp.
2
Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: tatsuya_ueno@med.pref.aomori.jp.
3
Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: chieko_murakami@med.pref.aomori.jp.
4
Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: yasuhito@ra2.so-net.ne.jp.
5
Department of Gastroenterology, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: qqsv9gnd@mild.ocn.ne.jp.
6
Department of Pathology, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: tsugumig@gmail.com.
7
Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: masahiko_tomiyama@med.pref.aomori.jp.

Abstract

Autoimmune diseases are sometimes associated with neoplasms. A 70-year-old Japanese woman with myelitis, seropositive for aquaporin-4 (AQP4) antibody, was diagnosed with neuromyelitis optica spectrum disorder (NMOSD); thereafter an esophageal squamous cell carcinoma was identified. Immunohistochemically, her cancer was anti-AQP4 antibody negative. Her symptoms, imaging findings and AQP4 titer markedly improved with corticosteroid and anti-cancer therapies. Although AQP4 may be a paraneoplastic antigen, paraneoplastic syndrome could not be definitively diagnosed in this case. Nevertheless, this is the first report of an association between AQP4 antibody-seropositive NMOSD and esophageal cancer. The possibility of underlying malignancy should be considered in patients diagnosed with NMOSD.

PMID:
28601284
DOI:
10.1016/j.jneuroim.2017.05.009
[Indexed for MEDLINE]

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