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Curr Opin Cell Biol. 2017 Oct;48:40-46. doi: 10.1016/j.ceb.2017.05.002. Epub 2017 Jun 7.

Mechanisms of cell competition emerging from Drosophila studies.

Author information

1
Department of Genetics, Department of Developmental and Molecular Biology, Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, United States. Electronic address: nicholas.baker@einstein.yu.edu.

Abstract

Cell competition was described in Drosophila as the loss from mosaic tissues of otherwise viable cells heterozygous for Ribosomal protein mutations ('Minutes'). Cell competition has now been described to occur between multiple other genotypes, such as cells differing in myc expression levels, or mutated for neoplastic tumor suppressors. Recent studies implicate innate immunity components, and possibly mechanical stress, compression and cell intercalation as a consequence of differential growth rates in competitive cell death. Competition to eliminate pre-neoplastic tumors makes use of signals and receptors also used in patterning the nervous system including Slit/Robo2 and Sas/PTP10D to recognize and extrude clones of mutant cells, at least where local epithelial cyto-architecture is favorable. Cell competition facilitates expansion of Drosophila tumors through host tissue, and in normal development may promote developmental robustness and longevity by selecting for optimal progenitor cells.

PMID:
28600967
PMCID:
PMC5591771
DOI:
10.1016/j.ceb.2017.05.002
[Indexed for MEDLINE]
Free PMC Article

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