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Dev Biol. 2017 Aug 1;428(1):188-203. doi: 10.1016/j.ydbio.2017.06.003. Epub 2017 Jun 7.

Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
2
Department of Surgery, Division of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Neurobiology & Anatomy, University of Utah School of Medicine, Salt Lake City, UT, USA.
3
Department of Molecular Biology, Princeton University, Princeton, NJ, USA. Electronic address: danelle@princeton.edu.

Abstract

Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like and Frizzled, to the establishment, local refinement, and global order of embryonic and postnatal hair follicles. We find that, similar to Fz6 mutants, the disordered hair patterns of Vangl2 mutants are refined over time and eventually corrected. In both mutants, we find that tissue-level reorientation occurs through locally coordinated follicle rotation at stereotyped locations. Strikingly, Vangl2 and Fz6 mutant follicles collectively rotate with opposing directionalities, suggesting that redundant core PCP signals contribute to their directed realignment. Consistently, global follicle alignment is not restored upon conditional ablation of both Vangl1 and Vangl2 genes. Instead, spatially distinct patterns of whorls and crosses emerge and persist even after a complete cycle of hair follicle regeneration. Thus, local refinement of hair follicles into higher order patterns can occur independently of the core PCP system, however, their global alignment with the body axes requires PCP function throughout morphogenesis, growth and regeneration.

KEYWORDS:

Celsr1; Epidermis; Fz6; Hair follicles; Planar cell polarity; Vangl2

PMID:
28599846
PMCID:
PMC5549468
DOI:
10.1016/j.ydbio.2017.06.003
[Indexed for MEDLINE]
Free PMC Article

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