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World J Gastroenterol. 2017 May 21;23(19):3565-3568. doi: 10.3748/wjg.v23.i19.3565.

Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report.

Author information

1
Zhi He, Bo-Ta Cui, Ting Zhang, Pan Li, Chu-Yan Long, Guo-Zhong Ji, Fa-Ming Zhang, Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China.

Abstract

Fecal microbiota transplantation (FMT) is a promising strategy that involves reconstruction of gut microbiota. Recently, it has been considered as a treatment of Crohn's disease (CD) and certain neurological diseases. Here, to the best of our knowledge, we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of epilepsy. During the 20 mo of follow-up, FMT has proved its efficacy in preventing relapse of seizures after withdrawing the antiepileptic drugs. Furthermore, this finding highlights the role of microbiota-gut-brain axis and inspires a novel treatment for epilepsy through remodeling gut microbiota.

KEYWORDS:

Brain-gut axis; Crohn’s disease; Epilepsy; Fecal microbiota transplantation; Gut microbiota

PMID:
28596693
PMCID:
PMC5442093
DOI:
10.3748/wjg.v23.i19.3565
[Indexed for MEDLINE]
Free PMC Article

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