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Neurology. 2017 Jul 4;89(1):46-52. doi: 10.1212/WNL.0000000000004057. Epub 2017 Jun 8.

Intake of dairy foods and risk of Parkinson disease.

Author information

1
From the Departments of Epidemiology (K.C.H., I.Y.K., M.W., M.G.W., A.A.), Nutrition (K.C.H., A.A.), Biostatistics (M.W.), and Environmental Health (M.G.W.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), Pennsylvania State University, University Park; Channing Laboratory (M.W., A.A.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston. kch460@mail.harvard.edu.
2
From the Departments of Epidemiology (K.C.H., I.Y.K., M.W., M.G.W., A.A.), Nutrition (K.C.H., A.A.), Biostatistics (M.W.), and Environmental Health (M.G.W.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), Pennsylvania State University, University Park; Channing Laboratory (M.W., A.A.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston.

Abstract

OBJECTIVE:

To prospectively examine the association between commonly consumed dairy products and the risk of Parkinson disease (PD) in women and men.

METHODS:

Analyses were based on data from 2 large prospective cohort studies, the Nurses' Health Study (n = 80,736) and the Health Professionals Follow-up Study (n = 48,610), with a total of 26 and 24 years of follow-up, respectively. Both US-based studies were conducted via mailed biennial questionnaires. Dietary intake was assessed with food frequency questionnaires administered repeatedly over the follow-up period. Incident cases of PD (n = 1,036) were identified via questionnaires and subsequently confirmed by reviewing medical records. We also conducted a meta-analysis to combine our study with 3 previously published prospective studies on total milk intake and PD risk and 1 study on total dairy intake and PD risk.

RESULTS:

While total dairy intake was not significantly associated with PD risk in our cohorts, intake of low-fat dairy foods was associated with PD risk. The pooled, multivariable-adjusted hazard ratio (HR) comparing people who consumed at least 3 servings of low-fat dairy per day to those who consumed none was 1.34 (95% confidence interval [CI] 1.01-1.79, p trend = 0.04). This association appeared to be driven by an increased risk of PD associated with skim and low-fat milk (HR 1.39, 95% CI 1.12-1.73, p trend <0.01). Results were similar in women and men (p for heterogeneity >0.05). In the meta-analysis, the pooled relative risk comparing extreme categories of total milk intake was 1.56 (95% CI 1.30-1.88), and the association between total dairy and PD became significant (HR 1.27, 95% CI 1.04-1.55).

CONCLUSIONS:

Frequent consumption of dairy products appears to be associated with a modest increased risk of PD in women and men.

PMID:
28596209
PMCID:
PMC5496517
DOI:
10.1212/WNL.0000000000004057
[Indexed for MEDLINE]
Free PMC Article

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