Format

Send to

Choose Destination
Surgeon. 2017 Oct;15(5):297-302. doi: 10.1016/j.surge.2017.04.004. Epub 2017 Jun 7.

Inflammation in tendinopathy.

Author information

1
Department of Public Health, Section of Orthopaedic and Trauma Surgery, School of Medicine and Surgery, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy. Electronic address: alessio.daddona@gmail.com.
2
Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London, E1 4DG, England, UK; Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, Salerno, Italy. Electronic address: n.maffulli@qmul.ac.uk.
3
Department of Molecular Medicine and Medical Biotechnology, School of Medicine, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy. Electronic address: sformisano@unisa.it.
4
Department of Public Health, Section of Orthopaedic and Trauma Surgery, School of Medicine and Surgery, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy. Electronic address: drosa@tin.it.

Abstract

Pain and functional limitation are frequent in symptomatic tendinopathy. The essential lesion of tendinopathy is a failed healing response. Understanding the cellular and molecular mechanisms involved in a failed healing response during the early stages of pathogenesis of tendinopathy would help to develop new and effective treatments. The role of inflammation in the development of tendon pathologies has been revived during the last few years, in particular during the first phases of tendinopathies, when "early tendinopathy" may not be clinically evident. This review outlines the possible molecular events that occur in the first phases of tendinopathy onset, stressing the role of pro-inflammatory cytokines, proteolytic enzymes, growth factors and healing genes in the development of tendon disorders.

KEYWORDS:

Early tendinopathy; Healing; Inflammation; Pro-inflammatory cytokines

PMID:
28596062
DOI:
10.1016/j.surge.2017.04.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center