Format

Send to

Choose Destination
Auris Nasus Larynx. 2018 Apr;45(2):281-285. doi: 10.1016/j.anl.2017.05.001. Epub 2017 Jun 5.

Endoscopic endonasal management of esthesioneuroblastoma: A retrospective multicenter study.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: tnakagawa@ent.kuhp.kyoto-u.ac.jp.
2
Department of Otolaryngology-Head and Neck Surgery, Oita University Faculty of Medicine, Yufu, Japan.
3
Department of Otorhinolaryngology-Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
4
Department of Otolaryngology-Head & Neck Surgery, Kumamoto University Hospital, Kumamoto, Japan.
5
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
6
Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
7
Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
8
Department of Otorhinolaryngology, Japanese Red Cross Medical Center, Tokyo, Japan.
9
Department of Otolaryngology, School of Medicine, Kyorin University, Tokyo, Japan.
10
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Nagoya City University, Nagoya, Japan.
11
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Abstract

OBJECTIVE:

The aim of the present study was to illustrate the safety and utility of the endoscopic endonasal approach (EEA) for the treatment of esthesioneuroblastomas (ENB).

METHODS:

We retrospectively reviewed patients with a diagnosis of ENB between March 2008 and February 2016 at 10 tertiary referral hospitals in Japan, and assessed demographic data, stage of disease, surgical approach, outcomes and postoperative complications.

RESULTS:

A total of 22 patients (10 males and 12 females; mean age at presentation, 49.0 years) underwent endoscopic endonasal resection of newly diagnosed ENBs. Dulguerov staging at presentation was T1, 6 patients; T2, 9 patients; T3, 5 patients; and T4, 2 patients. As surgical procedures, unilateral resection via EEA was performed in 12 patients aiming preservation of the contralateral olfactory system, and bilateral resection via EEA was done in 10 patients. Post-operative radiotherapy was done in 20 patients. Pathological margin studies revealed margin-free resections in 21 patients (95.5%). The mean period of follow-up was 44 months. Local recurrence was observed in one T2 patient 12 months after bilateral resection. All patients were alive at the last follow-up, and 21 patients showed no evidence of disease. No post-operative complications including bleeding, CSF leak and meningitis were identified. Preservation of olfactory function was achieved in 11 patients (91.7%).

CONCLUSION:

The results of the present study indicate the safety and utility of multilayer resection using EEA for treatment of ENBs.

KEYWORDS:

Anterior skull base; Endoscopic surgery; Multicenter study; Olfaction; Olfactory neuroblastoma

PMID:
28595773
DOI:
10.1016/j.anl.2017.05.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center