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PLoS One. 2017 Jun 8;12(6):e0178868. doi: 10.1371/journal.pone.0178868. eCollection 2017.

Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials.

Author information

1
Department of Cardiology, Taizhou People's Hospital, Taizhou, Jiangsu, China.
2
Department of Endocrinology, Taizhou People's Hospital, Taizhou, Jiangsu, China.

Abstract

OBJECTIVE:

To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials.

METHODS:

Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model.

RESULTS:

Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L. plantarum and reduction of LDL-C using L. plantarum or L. reuteri. No significant effects were found on TG and HDL-C levels after supplementation with probiotic Lactobacillus. While, subgroup analysis found significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.

CONCLUSION:

Consuming probiotic Lactobacillus, especially L. reuteri and L. plantarm, could reduce TC and LDL-C significantly. The study also suggested significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.

PMID:
28594860
PMCID:
PMC5464580
DOI:
10.1371/journal.pone.0178868
[Indexed for MEDLINE]
Free PMC Article

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