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Phytother Res. 2017 Aug;31(8):1209-1214. doi: 10.1002/ptr.5841. Epub 2017 Jun 8.

Phytoestrogen-Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women.

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Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, Moscow, Russia.
Centro Cardiologico Monzino, IRCCS, 20138, Milan, Italy.
Institute of General Pathology and Pathophysiology, 125315, Moscow, Russia.
Russian Cardiology Research and Production Complex, Moscow, Russia.
Federal Scientific Clinical Center for Resuscitation and Rehabilitation, 109240, Moscow, Russia.


The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen-rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima-media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow-up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima-media thickness between the two groups was not statistically significant at follow-up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women.


atherosclerosis; carotid intima-media thickness; climacteric syndrome; perimenopause; phytoestrogen-rich natural preparation; phytoestrogens

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