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Nat Rev Neurosci. 2017 Jul;18(7):389-403. doi: 10.1038/nrn.2017.56. Epub 2017 Jun 8.

Functional consequences of neuropeptide and small-molecule co-transmission.

Author information

1
Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
2
Department of Biology, Miami University, Oxford, Ohio 45056, USA.
3
Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA.

Abstract

Colocalization of small-molecule and neuropeptide transmitters is common throughout the nervous system of all animals. The resulting co-transmission, which provides conjoint ionotropic ('classical') and metabotropic ('modulatory') actions, includes neuropeptide- specific aspects that are qualitatively different from those that result from metabotropic actions of small-molecule transmitter release. Here, we focus on the flexibility afforded to microcircuits by such co-transmission, using examples from various nervous systems. Insights from such studies indicate that co-transmission mediated even by a single neuron can configure microcircuit activity via an array of contributing mechanisms, operating on multiple timescales, to enhance both behavioural flexibility and robustness.

PMID:
28592905
PMCID:
PMC5547741
DOI:
10.1038/nrn.2017.56
[Indexed for MEDLINE]
Free PMC Article

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