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Clin Infect Dis. 2017 Oct 15;65(8):1388-1395. doi: 10.1093/cid/cix524.

Effectiveness of Influenza Vaccines in Asthma: A Systematic Review and Meta-Analysis.

Author information

1
Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh,Scotland.
2
Nuffield Department of Primary Care Health Sciences, Oxford University.
3
Cardiff University, Institute of Primary Care and Public Health, Wales.
4
Health Protection Scotland, NHS National Services Scotland, Glasgow.
5
Centre of Academic Primary Care, University of Aberdeen.
6
Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, Child Life and Health, The University of Edinburgh, Scotland, United Kingdom.
7
Allergy Unit, 2nd Pediatric Clinic, University of Athens, Greece.
8
Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester.
9
National Heart and Lung Institute, Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London.
10
College of Medicine and Veterinary Medicine, The University of Edinburgh, Scotland, United Kingdom.

Abstract

There is uncertainty about the effectiveness of influenza vaccination in persons with asthma and its impact on asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma. This systematic review and meta-analysis involved searching 12 international databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiological studies (1970-2016). The risk of bias was low for 3 included RCTs. The quality of 3 included observational studies was moderate. The quality of evidence was very low for all study outcomes. Pooled vaccine effectiveness in 1825 persons with asthma from 2 test-negative design case-control studies was 45% (95% confidence interval [CI], 31%-56%) for laboratory-confirmed influenza. Pooled efficacy of live vaccines in reducing influenza was 81% (95% CI, 33%- 94%). Live vaccine reduced febrile illness by 72% (95% CI, 20%-90%). Influenza vaccine prevented 59%-78% of asthma attacks leading to emergency visits and/or hospitalizations. For persons with asthma, influenza vaccination may be effective in both reducing influenza infection and asthma attacks.

KEYWORDS:

asthma; immunization; influenza; laboratory confirmed influenza; vaccination

PMID:
28591866
PMCID:
PMC5850022
DOI:
10.1093/cid/cix524
[Indexed for MEDLINE]
Free PMC Article

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