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Cereb Cortex. 2018 Jul 1;28(7):2326-2339. doi: 10.1093/cercor/bhx133.

Temporally Segmented Directionality in the Motor Cortex.

Author information

1
Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
2
Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA, USA.
3
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
4
Centre for Brain Research, University of Auckland, Auckland, New Zealand.
5
Fivetran, San Francisco, CA, USA.
6
Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA.
7
Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USA.
8
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
9
Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA, USA.
10
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
11
University of Pittsburgh Brain Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

Developing models of the dynamic and complex patterns of information processing that take place during behavior is a major thrust of systems neuroscience. An underlying assumption of many models is that the same set of rules applies across different conditions. This has been the case for directional tuning during volitional movement; a single cosine function has been remarkably robust for describing the encoding of movement direction in different types of neurons, in many locations of the nervous system, and even across species. However, detailed examination of the tuning time course in motor cortex suggests that direction coding may be labile. Here, we show that there are discrete time epochs within single reaches, between which individual neurons change their tuning. Our findings suggest that motor cortical activity patterns may reflect consistent changes in the state of the control system during center-out reaching. These transitions are likely linked to different behavioral components, suggesting that the task defines changes in the operational structure of the control system.

PMID:
28591803
PMCID:
PMC5998963
[Available on 2019-07-01]
DOI:
10.1093/cercor/bhx133

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