Format

Send to

Choose Destination
Cereb Cortex. 2018 Jul 1;28(7):2439-2457. doi: 10.1093/cercor/bhx145.

Histamine Enhances Theta-Coupled Spiking and Gamma Oscillations in the Medial Entorhinal Cortex Consistent With Successful Spatial Recognition.

Author information

1
Department of Physiology, Collaborative Innovation Center for Brain Science, Third Military Medical University, Chongqing, China.
2
Brain Research Center, Third Military Medical University, Chongqing, China.
3
Department of Basic Psychology, School of Psychology, Third Military Medical University, Chongqing, China.
4
Department of Sleep and Psychology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.

Abstract

Encoding of spatial information in the superficial layers of the medial entorhinal cortex (sMEC) involves theta-modulated spiking and gamma oscillations, as well as spatially tuned grid cells and border cells. Little is known about the role of the arousal-promoting histaminergic system in the modification of information encoded in the sMEC in vivo, and how such histamine-regulated information correlates with behavioral functions. Here, we show that histamine upregulates the neural excitability of a significant proportion of neurons (16.32%, 39.18%, and 52.94% at 30 μM, 300 μM, and 3 mM, respectively) and increases local theta (4-12 Hz) and gamma power (low: 25-48 Hz; high: 60-120 Hz) in the sMEC, through activation of histamine receptor types 1 and 3. During spatial exploration, the strength of theta-modulated firing of putative principal neurons and high gamma oscillations is enhanced about 2-fold by histamine. The histamine-mediated increase of theta phase-locking of spikes and high gamma power is consistent with successful spatial recognition. These results, for the first time, reveal possible mechanisms involving the arousal-promoting histaminergic system in the modulation of spatial cognition.

PMID:
28591796
DOI:
10.1093/cercor/bhx145

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center