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Curr Opin Struct Biol. 2017 Jun;44:211-218. doi: 10.1016/j.sbi.2017.05.007. Epub 2017 Jun 4.

Structural features of glycan recognition among viral pathogens.

Author information

1
Verna and Marrs McLean Department of Biochemistry and Molecular Biology. Electronic address: shanker@bcm.edu.
2
Verna and Marrs McLean Department of Biochemistry and Molecular Biology.
3
Department of Molecular Virology and Microbiology.
4
Department of Molecular Virology and Microbiology; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States.
5
Verna and Marrs McLean Department of Biochemistry and Molecular Biology. Electronic address: vprasad@bcm.edu.

Abstract

Recognition and binding to host glycans present on cellular surfaces is an initial and critical step in viral entry. Diverse families of host glycans such as histo-blood group antigens, sialoglycans and glycosaminoglycans are recognized by viruses. Glycan binding determines virus-host specificity, tissue tropism, pathogenesis and potential for interspecies transmission. Viruses including noroviruses, rotaviruses, enteroviruses, influenza, and papillomaviruses have evolved novel strategies to bind specific glycans often in a strain-specific manner. Structural studies have been instrumental in elucidating the molecular determinants of these virus-glycan interactions, aiding in developing vaccines and antivirals targeting this key interaction. Our review focuses on these key structural aspects of virus-glycan interactions, particularly highlighting the different strain-specific strategies employed by viruses to bind host glycans.

PMID:
28591681
PMCID:
PMC5733725
DOI:
10.1016/j.sbi.2017.05.007
[Indexed for MEDLINE]
Free PMC Article

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