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Stem Cell Reports. 2017 Jun 6;8(6):1465-1471. doi: 10.1016/j.stemcr.2017.05.018.

Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration.

Author information

1
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA.
2
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: zon@enders.tch.harvard.edu.

Abstract

This perspective describes the usefulness of zebrafish as a model to study interaction of hematopoietic stem cells with the associated niche in vivo, explains how such interactions influence regeneration, migration, and clonality of HSCs, and defines their fate during differentiation.

KEYWORDS:

HSC; chemical screen; clonality; niche; zebrafish

PMID:
28591648
PMCID:
PMC5470329
DOI:
10.1016/j.stemcr.2017.05.018
[Indexed for MEDLINE]
Free PMC Article

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