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Cell Metab. 2017 Jun 6;25(6):1231-1242. doi: 10.1016/j.cmet.2017.04.032.

Gut-Brain Glucose Signaling in Energy Homeostasis.

Author information

1
Institut National de la Santé et de la Recherche Médicale, U1213, Lyon 69372, France; Université de Lyon, Lyon 69008, France; Université Lyon I, Villeurbanne 69622, France.
2
Institut National de la Santé et de la Recherche Médicale, U1213, Lyon 69372, France; Université de Lyon, Lyon 69008, France; Université Lyon I, Villeurbanne 69622, France. Electronic address: gilles.mithieux@inserm.fr.

Abstract

Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis. Intestinal gluconeogenesis induced by specific nutrients releases glucose, which is sensed by the nervous system surrounding the portal vein. This initiates a signal positively influencing parameters involved in glucose control and energy management controlled by the brain. This knowledge has extended our vision of the gut-brain axis, classically ascribed to gastrointestinal hormones. Our work raises several questions relating to the conditions under which intestinal gluconeogenesis proceeds and may provide its metabolic benefits. It also leads to questions on the advantage conferred by its conservation through a process of natural selection.

KEYWORDS:

brain glucose sensing; endogenous glucose production; energy homeostasis; food intake; glucose control; insulin sensitivity; intestinal gluconeogenesis

PMID:
28591631
DOI:
10.1016/j.cmet.2017.04.032
[Indexed for MEDLINE]
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