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Brain Res. 1985 Mar 18;330(1):150-3.

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation.

Abstract

Perforant path stimulation for 24 h evoked hippocampal granule cell spikes and epileptiform discharges throughout the stimulation period. After stimulation, hippocampal neurons that receive granule cell output were irreversibly damaged and the stimulated hippocampus of each rat revealed a selective loss of Timm stain in the mossy fiber pathway. These results provide evidence in vivo for a role for synaptic zinc in neurotransmission and/or seizure mechanisms.

PMID:
2859083
DOI:
10.1016/0006-8993(85)90017-4
[Indexed for MEDLINE]

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