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J Autism Dev Disord. 2017 Sep;47(9):2703-2709. doi: 10.1007/s10803-017-3188-z.

The Accuracy of the ADOS-2 in Identifying Autism among Adults with Complex Psychiatric Conditions.

Author information

1
Center for Mental Health Policy and Services Research, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, 3rd Floor, Philadelphia, PA, 19104, USA. maddoxb@upenn.edu.
2
Center for Autism Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. maddoxb@upenn.edu.
3
Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
4
Neuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
5
Center for Mental Health Policy and Services Research, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, 3rd Floor, Philadelphia, PA, 19104, USA.
6
Collaborative on Community Inclusion of Individuals with Psychiatric Disabilities, Department of Rehabilitation Sciences, Temple University, Philadelphia, PA, USA.
7
Center for Autism Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Abstract

The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), Module 4 is considered a "gold-standard" instrument for diagnosing autism spectrum disorder (ASD) in adults. Although the ADOS-2 shows good sensitivity and specificity in lab-based settings, it is unknown whether these results hold in community clinics that serve a more psychiatrically impaired population. This study is the first to evaluate the diagnostic accuracy of the ADOS-2 among adults in community mental health centers (nā€‰=ā€‰75). The ADOS-2 accurately identified all adults with ASD; however, it also had a high rate of false positives among adults with psychosis (30%). Findings serve as a reminder that social communication difficulties measured by the ADOS-2 are not specific to ASD, particularly in clinically complex settings.

KEYWORDS:

Adults; Autism Diagnostic Observation Schedule; Autism spectrum disorder; Community mental health; Psychosis

PMID:
28589494
PMCID:
PMC5813679
DOI:
10.1007/s10803-017-3188-z
[Indexed for MEDLINE]
Free PMC Article

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