Format

Send to

Choose Destination
Stem Cell Rev Rep. 2017 Jun;13(3):407-417. doi: 10.1007/s12015-017-9741-5.

Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases.

Author information

1
Cell and Tissue Engineering Laboratory, IRCCS Istituto Ortopedico Galeazzi, via Galeazzi, 4, 20161, Milan, Italy.
2
Regenerative Medicine Technologies Lab, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900, Lugano, Switzerland.
3
Unità di Traumatologia ed Ortopedia ORL, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900, Lugano, Switzerland.
4
Cell and Tissue Engineering Laboratory, IRCCS Istituto Ortopedico Galeazzi, via Galeazzi, 4, 20161, Milan, Italy. matteo.moretti@grupposandonato.it.
5
Regenerative Medicine Technologies Lab, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900, Lugano, Switzerland. matteo.moretti@grupposandonato.it.
6
Swiss Institute of Regenerative Medicine (SIRM), Via ai Söi, Taverne, Switzerland. matteo.moretti@grupposandonato.it.

Abstract

The skeleton supports and confers structure to the whole body but several pathological and traumatic conditions affect the bone tissue. Most of those pathological conditions are specific and different among different patients, such as bone defects due to traumatic injuries or bone remodeling alterations due to congenital diseases. In this context, the development of personalized therapies would be highly desirable. In recent years the advent of innovative techniques like bioprinting and microfluidic organ-on-chip raised hopes of achieving key tools helping the application of personalized therapies for bone diseases. In this review we will illustrate the latest progresses in the bioprinting of personalized bone grafts and generation of patient-specific bone-on-chip devices, describing current approaches and limitations and possible future improvements for more effective personalized bone grafts and disease models.

KEYWORDS:

Bioprinting; Bone tissue models; Microfluidics; Personalized medicine

PMID:
28589446
DOI:
10.1007/s12015-017-9741-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center