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Clin Case Rep. 2017 Apr 24;5(6):891-893. doi: 10.1002/ccr3.969. eCollection 2017 Jun.

Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia.

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Division of Malignant Hematology and Blood and Marrow Transplantation University of California San Francisco California.


The incidence of serum sickness following treatment of CLL with obinutuzumab has not been fully characterized, but is likely rare. Consideration should be given to this diagnosis in appropriate circumstances so that effective corticosteroid therapy can be initiated to alleviate inflammatory symptoms and organ dysfunction in a timely manner.


Chronic lymphocytic leukemia; monoclonal antibody; obinutuzumab; serum sickness

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