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Int J Obes (Lond). 2017 Sep;41(9):1420-1426. doi: 10.1038/ijo.2017.136. Epub 2017 Jun 7.

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner.

Author information

1
Department of Bioscience, Section for Zoophysiology, Aarhus University, Aarhus, Denmark.
2
Department of Public Health, Section for Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark.
3
Department of Biomedicine, The Danish Research Institute of Translational Neuroscience, Nordic EMBL Partnership for Molecular Medicine and Danish Diabetes Academy, Aarhus University, Aarhus, Denmark.
4
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
5
Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Risskov, Denmark.
6
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
7
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark.
8
Department of Endocrinology and Internal Medicine Medical Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.

Abstract

BACKGROUND/OBJECTIVES:

The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.

METHODS:

We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.

RESULTS:

Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.

CONCLUSIONS:

This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

PMID:
28588305
DOI:
10.1038/ijo.2017.136
[Indexed for MEDLINE]

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