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Acta Otolaryngol. 2017 Oct;137(10):1069-1076. doi: 10.1080/00016489.2017.1332428. Epub 2017 Jun 7.

A method to induce human cortical long-term potentiation by acoustic stimulation.

Lei G1,2,3,4, Zhao Z1,3,4,5,6, Li Y1,3,4,5,6, Yu L1, Zhang X7, Yan Y1, Ma X1, Wang Q1, Wang K1,2, Zhang D1,3,4, Shen W1,3,4, Qiao Y5,6, Yang S1,3,4.

Author information

1
a Department of Otorhinolaryngology, Head and Neck Surgery , Chinese PLA General Hospital , Beijing , China.
2
b Medical School, Nankai University , Tianjin , China.
3
c Key Laboratory of Hearing Impairment Science (Chinese PLA Medical School), Chinese Ministry of Education , Beijing , China.
4
d Beijing Key Laboratory of Hearing Impairment Prevention and Treatment , Beijing , China.
5
e Institute of Audiology and Balance Science , Xuzhou Medical University , Xuzhou , China.
6
f Clinical Hearing Center of Affiliated Hospital, Xuzhou Medical University , Xuzhou , China.
7
g Brainnetome Center, Institute of Automation, Chinese Academy of Sciences , Beijing , China.

Abstract

OBJECT:

Acoustic stimulation induced LTP in the human auditory cortex was successfully recorded for the first time by electroencephalography (EEG) using a stimulus of 1 kHz pure-tone in 2005. However, it was barely reproduced, given considerable challenges to reliably elicit and accurately record the enhanced potentials in vivo. The purpose of this paper was to explore whether acoustic stimuli other than 1 kHz pure-tone could generate LTP or not.

MEASURES:

To answer this question, we proposed a tetanic-stimulation paradigm of pure-tones, narrow-band noises (NBNs) and white noise (WN) to elicit LTP in human subjects.

RESULTS:

The results showed that pure-tones with different frequency could elicit LTP in human auditory cortex, and proved for the first time that NBNs and WN could also achieve the same goal. Interestingly, it was also shown that the noises with certain bandwidth induced the greatest LTP and the WN induced LTP had the least variation over time and across subjects in comparison with pure-tones and NBNs.

CONCLUSIONS:

In light of the results, we suggested to use the paradigm for broader studies of human in vivo cortical plasticity.

KEYWORDS:

Long-term potentiation; auditory evoked LTP; auditory evoked potential; cortical plasticity; tetanic stimulation

PMID:
28587562
DOI:
10.1080/00016489.2017.1332428
[Indexed for MEDLINE]

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