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Int J Mol Sci. 2017 Jun 5;18(6). pii: E1195. doi: 10.3390/ijms18061195.

Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling.

Author information

1
College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. evolutionantony@gmail.com.
2
College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. aravinthchandra@gmail.com.
3
Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, Sunchang-gun, Jeollabuk-do 56015, Korea. wooju0717@hanmail.net.
4
Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, Sunchang-gun, Jeollabuk-do 56015, Korea. khmoon@korea.kr.
5
Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, Sunchang-gun, Jeollabuk-do 56015, Korea. roofdg@hanmail.net.
6
Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, Sunchang-gun, Jeollabuk-do 56015, Korea. soyoun5005@hanmail.net.
7
College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. cwkang@chonbuk.ac.kr.
8
College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. namsoo@jbnu.ac.kr.
9
College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. jhkim1@jbnu.ac.kr.

Abstract

Aronia melanocarpa (Michx.) Ell. belongs to the Rosaceae family. The purpose of this study is to explore the gastroprotective effect of the Aronia melanocarpa hydro-alcoholic extract (AMHAE) against ethanol-induced gastric ulcer in a rat model. Different concentrations (50, 100, and 200 mg/kg) of AMHAE, or 30 mg/kg of omeprazole, significantly inhibited the gastric injury formation. The ethanol-induced ulcer group showed significant increases of malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor (TNF)-α, nuclear factor-kappaB p65 (NF-κB p65), and monocyte chemoattractant protein (MCP)-1, and decreased activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), and interleukin (IL)-4. However, AMHAE (200 mg/kg) pretreatment significantly reversed the altered pathophysiological levels of these biomolecules to near normal stages. The gastroprotective activity of AMHAE was abolished by pretreatment with l-NAME, naloxone, capsazepine, and indomethacin, demonstrating the participation of nitric oxide (NO), opioids, TRPV (vanilloid receptor-related transient receptor potential), and prostaglandins in AMHAE-assisted gastroprotection against ethanol-induced gastric injuries. This gastroprotective effect of AMHAE might be due to the downregulation of TNF-α-based NF-κB, MCP-1 signaling and strong antioxidant properties.

KEYWORDS:

Aronia melanocarpa; ethanol-induced gastric ulcer; gastroprotective activity; ulcer index

PMID:
28587230
PMCID:
PMC5486018
DOI:
10.3390/ijms18061195
[Indexed for MEDLINE]
Free PMC Article

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