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Molecules. 2017 Jun 3;22(6). pii: E930. doi: 10.3390/molecules22060930.

Laurus nobilis: Composition of Essential Oil and Its Biological Activities.

Author information

1
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy. lcaputo@unisa.it.
2
Istituto di Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche (ISA-CNR), Via Roma 64, 83100 Avellino, Italy. mena@isa.cnr.it.
3
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy. luceia.souza@ufrgs.br.
4
Post-Doctoral by National Counsel of Technological and Scientific Development (CNPq/Brazil), 70000-000 Brasília, Brazil. luceia.souza@ufrgs.br.
5
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy. luigialiberti83@libero.it.
6
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy. ldemartino@unisa.it.
7
Istituto di Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche (ISA-CNR), Via Roma 64, 83100 Avellino, Italy. fratianni@isa.cnr.it.
8
Dipartimento di Agricoltura, Ambiente e Alimenti-Università del Molise, Via de Sanctis snc, 86100 Campobasso, Italy. coppola@unimol.it.
9
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy. defeo@unisa.it.

Abstract

Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds were identified, accounting for 91.6% of the total oil. 1,8-Cineole (31.9%), sabinene (12.2%), and linalool (10.2%) were the main components. Antimicrobial and antifungal activities of EO and 1,8-cineole were determined in vitro. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line, as well as the influence of the EO on the expression of adenylate cyclase 1 (ADCY1), suggesting possible oil effects on the Central Nervous System.

KEYWORDS:

Central Nervous System (CNS); Laurus nobilis L.; adenylate cyclase 1 (ADCY1); antibacterial activity; antifungal activity; cytotoxicity; essential oil

PMID:
28587201
PMCID:
PMC6152719
DOI:
10.3390/molecules22060930
[Indexed for MEDLINE]
Free PMC Article

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