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PLoS One. 2017 Jun 6;12(6):e0178860. doi: 10.1371/journal.pone.0178860. eCollection 2017.

Patients with schizophrenia activate behavioural intentions facilitated by counterfactual reasoning.

Author information

1
Department of Psychiatry, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat, Spain.
2
Department of Clinical Sciences, School of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain.
3
Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
4
Statistical Advisory Service, Bellvitge Biomedical Institute-IDIBELL, L'Hospitalet de Llobregat, Spain.
5
Faculty of Medicine and Health Sciences, University Rovira i Virgili, Tarragona, Spain.
6
Department of Psychology, University of Girona, Girona, Spain.

Abstract

METHOD:

The main variables assessed were: answer to complete a target task (wrong or correctly), and percentage gain in the reaction time (RT) to complete a target task correctly depending on whether the prime was a counterfactual or a neutral-control cue. These variables were assessed in 37 patients with schizophrenia and 37 healthy controls. Potential associations with clinical status and socio-demographic characteristics were also explored.

RESULTS:

When a counterfactual prime was presented, the probability of giving an incorrect answer was lower for the entire sample than when a neutral prime was presented (OR 0.58; CI 95% 0.42 to 0.79), but the schizophrenia patients showed a higher probability than the controls of giving an incorrect answer (OR 3.89; CI 95% 2.0 to 7.6). Both the schizophrenia patients and the controls showed a similar percentage gain in RT to a correct answer of 8%.

CONCLUSIONS:

Challenging the results of previous research, our findings suggest a normal activation of behavioural intentions facilitated by CFT in schizophrenia. Nevertheless, the patients showed more difficulty than the controls with the task, adding support to the concept of CFT as a potential new target for consideration in future therapeutic approaches for this illness.

PMID:
28586400
PMCID:
PMC5460856
DOI:
10.1371/journal.pone.0178860
[Indexed for MEDLINE]
Free PMC Article

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