Format

Send to

Choose Destination
Sports Med Open. 2017 Dec;3(1):22. doi: 10.1186/s40798-017-0089-9. Epub 2017 Jun 5.

Efficacy and Tolerability of Peritendinous Hyaluronic Acid in Patients with Supraspinatus Tendinopathy: a Multicenter, Randomized, Controlled Trial.

Author information

1
Department of Orthopaedic Surgery and Sports Medicine, Clínica CEMTRO, Madrid, Spain.
2
Department of Sports Medicine, Centre d'Estudis d'Alt Rendiment Esportiu (CEARE), Consell Català de l'Esport, Barcelona, Spain.
3
Department of Sports Medicine, AMS - Centro Médico del Ejercicio, Málaga, Spain.
4
Department of Sports Medicine, IVRE-Institut Valencià de Recuperació Esportiva, Valencia, Spain.
5
Department of Clinical Research, OPKO Health Europe, Plaza Europa, 13-15, Hospitalet de Llobregat, 08908, Barcelona, Spain. lvarela@opko.com.
6
Department of Physical Therapy, AMS-Centro Médico del Ejercicio, Málaga, Spain.
7
Medical Department, OPKO Health Europe, Barcelona, Spain.

Abstract

BACKGROUND:

Physical therapy and peritendinous hyaluronic acid (HA) injections have both shown promising results in the treatment of shoulder tendinopathies. However, the superiority of treatment combining physical therapy and HA is unclear.

METHODS:

Patients with ultrasound-confirmed supraspinatus tendinopathy were randomized to receive either physical therapy + subacromial HA injections or physical therapy only. Treatment efficacy was assessed using a Visual Analog Scale (VAS) for pain and an Activities of Daily Living (ADL) scale. Other measures were the number of rehabilitation sessions and days needed for recovery, the Tampa Scale for Kinesiophobia (TSK), and the physician and patient's perception of efficacy and tolerability. Patients were followed up for 90 days.

RESULTS:

Overall, VAS and ADL scores showed a progressive decrease during the follow-up (P < 0.01 at all visits for both groups), without significant differences between groups. The TSK score decreased significantly more in the HA group than in the control group (3.6 vs. 2.4; P < 0.001). Patients in the control group needed more rehabilitation sessions (28 vs. 22 in the HA group; P = 0.006) and more days for returning to their pre-injury activity (32 vs. 20 in the HA group; P = 0.013). Both patients and investigators perceived higher efficacy in the HA group than in the control group (P = 0.034). Both treatments were safe and well tolerated.

CONCLUSIONS:

Subacromial HA injections combined with physical therapy have high efficacy in the treatment of supraspinatus tendinopathy, leading to an earlier return to pre-injury activity and the need for fewer rehabilitation sessions, which may benefit both patients and the healthcare system.

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center