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J Glob Infect Dis. 2017 Apr-Jun;9(2):66-72. doi: 10.4103/0974-777X.205173.

Epidemiology of Rotavirus in the Iranian Children: A Systematic Review and Meta-analysis.

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Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute, Tehran, Iran.
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Nutrition, School of Health, Zabol University of Medical Sciences, Zabol, Iran.
Department of Microbiology, School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.


Rotavirus is associated with increased risk for severe diarrhea in infants and young children worldwide. This systematic review and meta-analysis was performed to determine the prevalence rate of rotavirus from different parts of Iran and provide an overall relative frequency (RF) for Iran. We performed a systematic literature review from several databases including PubMed, ISI Web of Science, Scopus, OVID, MAG IRAN, IranMedex, and Iranian Scientific Information Database. We searched the following keywords: "rotavirus," "rotavirus infection," "acute gastroenteritis," "diarrhea," "children," "infant," and "Iran." The purpose of this study was to report the prevalence of rotavirus with the application of meta-analysis. We selected 43 researches out of 1147 for our study. From all the samples, the pooled estimate of prevalence (95% confidence interval) =39.9% (0.396%-0.409%) were rotavirus positive. It should be noted that rotavirus infection's RF varied from 6.4% to 79.3% in Birjand and Tehran Provinces, respectively. Thereupon, it is divergent in different studies. According to our study result, rotavirus RF has a wide range in Iran and is associated with diarrhea in children. Thus, further researches should be taken to minimize the emergence and transmission of rotavirus.


Children; Iran; diarrhea; infant; rotavirus; rotavirus infection

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