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EBioMedicine. 2017 Jun;20:193-201. doi: 10.1016/j.ebiom.2017.04.029. Epub 2017 Apr 24.

Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection.

Author information

1
Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Brain Science, Key Laboratory of Medical Molecular Virology of Ministry of Education/Ministry of Health and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China.
2
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
3
State Key Laboratory of Pharmaceutical Biotechnology, Department of Biological Science and Technology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.
4
Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Brain Science, Key Laboratory of Medical Molecular Virology of Ministry of Education/Ministry of Health and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China. Electronic address: shibojiang@fudan.edu.cn.
5
Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Brain Science, Key Laboratory of Medical Molecular Virology of Ministry of Education/Ministry of Health and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China. Electronic address: lul@fudan.edu.cn.
6
Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Brain Science, Key Laboratory of Medical Molecular Virology of Ministry of Education/Ministry of Health and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China. Electronic address: jiayizhang@fudan.edu.cn.

Abstract

Human infants with congenital Zika virus (ZIKV) infection exhibit a range of symptoms including microcephaly, intracranial calcifications, macular atrophy and arthrogryposis. More importantly, prognosis data have lagged far behind the recent outbreak of ZIKV in 2015. In this work, we allow congenitally ZIKV-infected mice to grow into puberty. These mice exhibited motor incoordination and visual dysfunctions, which can be accounted by anatomical defects in the retina and cerebellar cortex. In contrary, anxiety level of the ZIKV-infected mice is normal. The spectrum of anatomical and behavioral deficits is consistent across different mice. Our data provided evidence that may help predict the public health burden in terms of prognosis of ZIKV-related congenital brain malformations in an animal model. Our study provided behavioral evaluation for the prognosis of congenital ZIKV infection and provides a platform for screening and evaluation of drugs candidates and treatment aiming at improving regeneration of infected neurons to prevent sequelae caused by ZIKV infection of fetus.

KEYWORDS:

Congenital Zika syndrome; Intracranial calcifications; Prognosis evaluation; Visual and motor dysfunctions; ZIKV

PMID:
28583742
PMCID:
PMC5478201
DOI:
10.1016/j.ebiom.2017.04.029
[Indexed for MEDLINE]
Free PMC Article

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