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Trends Mol Med. 2017 Jul;23(7):580-582. doi: 10.1016/j.molmed.2017.05.008. Epub 2017 Jun 2.

The Boosting Potential of Bacteria in Cancer Immunotherapy.

Author information

1
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
2
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA. Electronic address: derekwainwright@northwestern.edu.

Abstract

Salmonella Typhimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review new observations that support the potential of utilizing modified bacteria to enhance antitumor immunity. We also discuss the implications of these findings for clinical applications, including immune checkpoint blockade therapies.

PMID:
28583420
PMCID:
PMC5515260
DOI:
10.1016/j.molmed.2017.05.008
[Indexed for MEDLINE]
Free PMC Article

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