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Life Sci. 2017 Jun 2. pii: S0024-3205(17)30276-X. doi: 10.1016/j.lfs.2017.06.002. [Epub ahead of print]

The impact of obesity on neurodegenerative diseases.

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Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, 88704-900 Tubarão, SC, Brazil.
Laboratory Pharmacology and Pathophysiology of Skin, Department of Pharmacology, Federal University of Paraná, Av. Coronel Franscisco Heráclito dos Santos, 210, 81531-970 Curitiba, PR, Brazil. Electronic address:


Neurodegenerative diseases are a growing health concern. The increasing incidences of these disorders have a great impact on the patients' quality of life. Although the mechanisms of neurodegenerative diseases are still far from being clarified, several studies look for new discoveries about their pathophysiology and prevention. Furthermore, evidence has shown a strong correlation between obesity and the development of Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolic changes caused by overweight are related to damage to the central nervous system (CNS), which can lead to neural death, either by apoptosis or cell necrosis, as well as alter the synaptic plasticity of the neuron. This review aims to show the association between neurodegenerative diseases, focusing on AD and PD, and metabolic alterations.


Alzheimer's disease; Neurodegenerative diseases; Obesity; Parkinson's disease

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