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Stem Cell Res Ther. 2017 Jun 6;8(1):137. doi: 10.1186/s13287-017-0576-4.

Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure.

Author information

1
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University, 79 Qingchun Road, Hangzhou, 310006, China.
2
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University, 79 Qingchun Road, Hangzhou, 310006, China. ljli@zju.edu.cn.

Abstract

Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, published articles have shown that MSCs work in liver failure by secreting trophic and immunomodulatory factors as well as extracellular vesicles (EVs) before transdifferentiation. In particular,MSC-derived EVs have shown similar curative effects as MSCs. Here we review the role of MSCsĀ as well as their derived factors and EVs in liver failure and discuss the use of MSC-derived EVs instead of intact MSCs in treating liver failure.

KEYWORDS:

Exosome; Extracellular vesicles; Liver failure; Liver regeneration; Mesenchymal stem cell

PMID:
28583199
PMCID:
PMC5460333
DOI:
10.1186/s13287-017-0576-4
[Indexed for MEDLINE]
Free PMC Article

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