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Nat Microbiol. 2017 Jun 5;2:17092. doi: 10.1038/nmicrobiol.2017.92.

A decade of discovery: CRISPR functions and applications.

Author information

1
Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, 400 Dan Allen Drive, Campus Box 7624, Raleigh, North Carolina 27695-7624, USA.
2
DuPont Nutrition and Health, BP10, 86220 Dangé-Saint-Romain, France.

Abstract

This year marks the tenth anniversary of the identification of the biological function of CRISPR-Cas as adaptive immune systems in bacteria. In just a decade, the characterization of CRISPR-Cas systems has established a novel means of adaptive immunity in bacteria and archaea and deepened our understanding of the interplay between prokaryotes and their environment, and CRISPR-based molecular machines have been repurposed to enable a genome editing revolution. Here, we look back on the historical milestones that have paved the way for the discovery of CRISPR and its function, and discuss the related technological applications that have emerged, with a focus on microbiology. Lastly, we provide a perspective on the impacts the field has had on science and beyond.

PMID:
28581505
DOI:
10.1038/nmicrobiol.2017.92
[Indexed for MEDLINE]

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