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J Korean Med Sci. 2017 Jul;32(7):1160-1165. doi: 10.3346/jkms.2017.32.7.1160.

Comparison of Electroencephalography (EEG) Coherence between Major Depressive Disorder (MDD) without Comorbidity and MDD Comorbid with Internet Gaming Disorder.

Author information

1
Department of Psychiatry, Chung-Ang University Medical Center, Seoul, Korea.
2
Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Korea.
3
School Mental Health Resources and Research Center, Kyungpook National University Children's Hospital, Daegu, Korea.
4
Department of Psychiatry, Chung-Ang University Medical Center, Seoul, Korea. sunmikim706@gmail.com.

Abstract

Internet gaming disorder (IGD) has many comorbid psychiatric problems including major depressive disorder (MDD). In the present study, we compared the neurobiological differences between MDD without comorbidity (MDD-only) and MDD comorbid with IGD (MDD+IGD) by analyzing the quantitative electroencephalogram (QEEG) findings. We recruited 14 male MDD+IGD (mean age, 20.0 ± 5.9 years) and 15 male MDD-only (mean age, 20.3 ± 5.5 years) patients. The electroencephalography (EEG) coherences were measured using a 21-channel digital EEG system and computed to assess synchrony in the frequency ranges of alpha (7.5-12.5 Hz) and beta (12.5-35.0 Hz) between the following 12 electrode site pairs: inter-hemispheric (Fp1-Fp2, F7-F8, T3-T4, and P3-P4) and intra-hemispheric (F7-T3, F8-T4, C3-P3, C4-P4, T5-O1, T6-O2, P3-O1, and P4-O2) pairs. Differences in inter- and intra-hemispheric coherence values for the frequency bands between groups were analyzed using the independent t-test. Inter-hemispheric coherence value for the alpha band between Fp1-Fp2 electrodes was significantly lower in MDD+IGD than MDD-only patients. Intra-hemispheric coherence value for the alpha band between P3-O1 electrodes was higher in MDD+IGD than MDD-only patients. Intra-hemispheric coherence values for the beta band between F8-T4, T6-O2, and P4-O2 electrodes were higher in MDD+IGD than MDD-only patients. There appears to be an association between decreased inter-hemispheric connectivity in the frontal region and vulnerability to attention problems in the MDD+IGD group. Increased intra-hemisphere connectivity in the fronto-temporo-parieto-occipital areas may result from excessive online gaming.

KEYWORDS:

Coherence; Internet Gaming Disorder; Major Depressive Disorder; Quantitative Electroencephalogram

PMID:
28581274
PMCID:
PMC5461321
[Available on 2017-07-01]
DOI:
10.3346/jkms.2017.32.7.1160
[Indexed for MEDLINE]
Free PMC Article

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