Format

Send to

Choose Destination
Neurochem Int. 2018 Jul;117:114-125. doi: 10.1016/j.neuint.2017.05.019. Epub 2017 Jun 1.

Neuroketotherapeutics: A modern review of a century-old therapy.

Author information

1
University of Kansas Alzheimer's Disease Center, KS, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, KS, USA.
2
University of Kansas Alzheimer's Disease Center, KS, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, KS, USA; Department of Neurology, University of Kansas Medical Center, KS, USA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, KS, USA. Electronic address: rswerdlow@kumc.edu.

Abstract

Neuroketotherapeutics represent a class of bioenergetic medicine therapies that feature the induction of ketosis. These therapies include medium-chain triglyceride supplements, ketone esters, fasting, strenuous exercise, the modified Atkins diet, and the classic ketogenic diet. Extended experience reveals persons with epilepsy, especially pediatric epilepsy, benefit from ketogenic diets although the mechanisms that underlie its effects remain unclear. Data indicate ketotherapeutics enhance mitochondrial respiration, promote neuronal long-term potentiation, increase BDNF expression, increase GPR signaling, attenuate oxidative stress, reduce inflammation, and alter protein post-translational modifications via lysine acetylation and β-hydroxybutyrylation. These properties have further downstream implications involving Akt, PLCγ, CREB, Sirtuin, and mTORC pathways. Further studies of neuroketotherapeutics will enhance our understanding of ketone body molecular biology, and reveal novel central nervous system therapeutic applications.

KEYWORDS:

Alzheimer's disease; Bioenergetics; Ketogenic diet; Ketone bodies; Mitochondria; β-hydroxybutyrate

PMID:
28579059
PMCID:
PMC5711637
DOI:
10.1016/j.neuint.2017.05.019
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center