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Public Health Nutr. 2017 Jul;20(10):1816-1824. doi: 10.1017/S1368980017000921. Epub 2017 Jun 5.

25-Hydroxyvitamin D supplementation and health-service utilization for upper respiratory tract infection in young children.

Author information

1
1Li Ka Shing Knowledge Institute,St. Michael's Hospital,209 Victoria Street,Toronto,ON,Canada,M5B 1T8.
2
3Child Health Evaluative Sciences,The Hospital for Sick Children,Toronto,ON,Canada.
3
2Department of Nutritional Sciences, Faculty of Medicine,University of Toronto,Toronto,ON,Canada.
4
4Institute of Health Policy,Management and Evaluation,University of Toronto,Toronto,ON,Canada.

Abstract

OBJECTIVE:

Upper respiratory tract infections (URTI) are the most common and costly condition of childhood. Low vitamin D levels have been hypothesized as a risk factor for URTI. The primary objective was to determine if serum vitamin D levels were associated with health-service utilization (HSU) for URTI including hospital admission, emergency department visits and outpatient sick visits. The secondary objectives were to determine whether oral vitamin D supplementation in pregnancy or childhood was associated with HSU for URTI.

DESIGN:

Cohort study. HSU was determined by linking each child's provincial health insurance number to health administrative databases. Multivariable quasi Poisson regression was used to evaluate the association between 25-hydroxyvitamin D, vitamin D supplementation and HSU for URTI.

SETTING:

Toronto, Canada.

SUBJECTS:

Children participating in the TARGet Kids! network between 2008 and 2013.

RESULTS:

Healthy children aged 0-5 years (n 4962) were included; 52 % were male and mean 25-hydroxyvitamin D was 84 nmol/l (range 11-355 nmol/l). There were 105 (2 %), 721 (15 %) and 3218 (65 %) children with at least one hospital admission, emergency department visit or outpatient sick visit for URTI, respectively. There were no statistically significant associations between 25-hydroxyvitamin D or vitamin D supplementation and HSU for URTI.

CONCLUSIONS:

A clinically meaningful association between vitamin D (continuously and dichotomized at <50 and <75 nmol/l) and HSU for URTI was not identified. While vitamin D may have other benefits for health, reducing HSU for URTI does not appear to be one of them.

KEYWORDS:

25-Hydroxyvitamin D; Early childhood; Health-service utilization; Upper respiratory infection; Vitamin D

PMID:
28578751
DOI:
10.1017/S1368980017000921
[Indexed for MEDLINE]

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