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Respir Res. 2017 Jun 2;18(1):112. doi: 10.1186/s12931-017-0598-6.

Prediction of long-term clinical outcomes using simple functional exercise performance tests in patients with COPD: a 5-year prospective cohort study.

Author information

1
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. sarah.crook@uzh.ch.
2
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
3
Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Abstract

The 1-min sit-to-stand (1-min STS) test and handgrip strength test have been proposed as simple tests of functional exercise performance in chronic obstructive pulmonary disease (COPD) patients. We assessed the long-term (5-year) predictive performance of the 1-min sit-to-stand and handgrip strength tests for mortality, health-related quality of life (HRQoL) and exacerbations in COPD patients. In 409 primary care patients, we found the 1-min STS test to be strongly associated with long-term morality (hazard ratio per 3 more repetitions: 0.81, 95% CI 0.65 to 0.86) and moderately associated with long-term HRQoL. Neither test was associated with exacerbations. Our results suggest that the 1-min STS test may be useful for assessing the health status and long-term prognosis of COPD patients. This study was registered at http://www.clinicaltrials.gov/ (NCT00706602, 25 June 2008).

KEYWORDS:

COPD; Exacerbations; HRQoL; Longitudinal; Mortality; Prediction

PMID:
28578705
PMCID:
PMC5457551
DOI:
10.1186/s12931-017-0598-6
[Indexed for MEDLINE]
Free PMC Article

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