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J Pediatr. 2017 Aug;187:323-327. doi: 10.1016/j.jpeds.2017.04.061. Epub 2017 May 31.

Low Retinol-Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection.

Author information

1
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN; Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center (UTHSC), Memphis, TN.
2
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN.
3
Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.
4
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA.
5
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN; Department of Pediatrics, UTHSC, Memphis, TN; Le Bonheur Children's Hospital, Memphis, TN.
6
Department of Pediatrics, UTHSC, Memphis, TN; Le Bonheur Children's Hospital, Memphis, TN.

Abstract

Retinol binding protein and vitamin D were measured in children aged <5 years hospitalized with lower respiratory tract infection and respiratory syncytial virus and/or human metapneumovirus detections. Low vitamin levels were observed in 50% of the children and were associated with significantly elevated risk of the need for intensive care unit admission and invasive mechanical ventilation.

KEYWORDS:

intensive care; mechanical ventilation; paramyxovirus; respiratory infection; respiratory tract; vitamin levels

PMID:
28578159
PMCID:
PMC5588918
DOI:
10.1016/j.jpeds.2017.04.061
[Indexed for MEDLINE]
Free PMC Article

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