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BMC Neurol. 2017 Jun 2;17(1):105. doi: 10.1186/s12883-017-0885-3.

The effectiveness of creatine treatment for Parkinson's disease: an updated meta-analysis of randomized controlled trials.

Author information

1
Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, No.2 Wenming Road, Zhanjiang, Guangdong, 524023, People's Republic of China.
2
Department of Neurology, Affiliated Hospital of Guangdong Medical University, No.2 Wenming Road, Zhanjiang, Guangdong, 524023, People's Republic of China.
3
Department of Neurology, Chenzhou No. 1 People's Hospital, Chenzhou, People's Republic of China.
4
Graduate School, Guangzhou Medical University, Guangzhou, City, People's Republic of China.
5
Department of Pathology, People's Hospital of Wuhan University, Wuhan City, People's Republic of China.
6
Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, No.2 Wenming Road, Zhanjiang, Guangdong, 524023, People's Republic of China. liuzhou102@126.com.
7
Department of Neurology, Affiliated Hospital of Guangdong Medical University, No.2 Wenming Road, Zhanjiang, Guangdong, 524023, People's Republic of China. liuzhou102@126.com.
8
Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, No.2 Wenming Road, Zhanjiang, Guangdong, 524023, People's Republic of China. 176878237@qq.com.

Abstract

BACKGROUND:

The effectiveness of creatine in treating Parkinson's disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue.

METHODS:

The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, and outcomes measured by the Total Unified Parkinson's Disease Rating Scale (UPDRS) and the Schwab & England Scale were analyzed.

RESULTS:

Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed.

CONCLUSIONS:

Creatine has no observed benefit in PD patients, although more correlated studies are still needed.

KEYWORDS:

Creatine; Meta-analysis; Mitochondrial dysfunction; Parkinson’s disease

PMID:
28577542
PMCID:
PMC5457735
DOI:
10.1186/s12883-017-0885-3
[Indexed for MEDLINE]
Free PMC Article

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