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Curr Opin Neurobiol. 2017 Jun;44:186-192. doi: 10.1016/j.conb.2017.03.021. Epub 2017 May 31.

Wake-sleep circuitry: an overview.

Author information

1
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States. Electronic address: csaper@bidmc.harvard.edu.
2
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.

Abstract

Although earlier models of brain circuitry controlling wake-sleep focused on monaminergic and cholinergic arousal systems, recent evidence indicates that these play mainly a modulatory role, and that the backbone of the wake-sleep regulatory system depends upon fast neurotransmitters, such as glutmate and GABA. We review here recent advances in understanding the role these systems play in controlling sleep and wakefulness.

PMID:
28577468
PMCID:
PMC5531075
DOI:
10.1016/j.conb.2017.03.021
[Indexed for MEDLINE]
Free PMC Article

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