Format

Send to

Choose Destination
Acta Diabetol. 2017 Aug;54(8):769-773. doi: 10.1007/s00592-017-1010-1. Epub 2017 Jun 2.

Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra-widefield fluorescein angiography: a pilot study.

Author information

1
Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina 60, Milan, 20132, Italy.
2
G. B. Bietti Foundation-IRCCS, Rome, Italy.
3
Eye Clinic, Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
4
Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina 60, Milan, 20132, Italy. giuseppe.querques@hotmail.it.

Abstract

AIMS:

To investigate the effect of dexamethasone intravitreal implant on peripheral ischemia in patients affected by diabetic macular edema (DME).

METHODS:

Patients with treatment-naïve diabetic retinopathy (DR) undergoing intravitreal dexamethasone implant for DME between October 2015 and March 2017 were enrolled. Patients underwent a comprehensive ocular examination at baseline (<2 weeks before treatment) and 10 ± 2 weeks after dexamethasone implant including best-corrected visual acuity (BCVA), intraocular pressure, optical coherence tomography, ultra-widefield (UWF) retinography and UWF fluorescein angiography (UWFA).

RESULTS:

Nine eyes of seven consecutive patients (five males; mean age 66.4 ± 6.7 years) were enrolled. Mean duration of DR was 12.3 ± 8.4 years. Mean interval between UWFA acquisitions was 12.1 ± 2.1 weeks, and the mean interval between intravitreal injection and UWFA acquisition was 11.0 ± 1.6 weeks. Mean pre- and post-injection BCVA was 0.30 ± 0.20 and 0.21 ± 0.14 logMAR (p = 0.06), respectively. Mean pre- and post-injection central macular thickness was 449.8 ± 92.5 and 356.3 ± 52.4 μm (p = 0.03), respectively. Mean pre- and post-injection ischemic index was 24.0 ± 25.0 and 9.8 ± 12.1% (p = 0.0427), respectively.

CONCLUSIONS:

Intravitreal dexamethasone implant reduces peripheral retina ischemia in patients with DR.

KEYWORDS:

After intravitreal dexamethasone implant; Diabetic macular edema; Diabetic retinopathy; Ischemic index; Ultra-widefield fluorescein angiography

PMID:
28577137
DOI:
10.1007/s00592-017-1010-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center