Format

Send to

Choose Destination
J Physiol Paris. 2016 Nov;110(4 Pt A):372-381. doi: 10.1016/j.jphysparis.2017.05.004. Epub 2017 Jun 3.

Absence seizure susceptibility correlates with pre-ictal β oscillations.

Author information

1
Stanford Neurosciences Graduate Training Program, United States; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, United States.
2
Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, United States; Gladstone Institutes, San Francisco, CA 94158, United States.
3
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, United States. Electronic address: john.huguenard@stanford.edu.

Abstract

Absence seizures are generalized, cortico-thalamo-cortical (CTC) high power electroencephalographic (EEG) or electrocorticographic (ECoG) events that initiate and terminate suddenly. ECoG recordings of absence seizures in animal models of genetic absence epilepsy show a sudden spike-wave-discharge (SWD) onset that rapidly emerges from normal ECoG activity. However, given that absence seizures occur most often during periods of drowsiness or quiet wakefulness, we wondered whether SWD onset correlates with pre-ictal changes in network activity. To address this, we analyzed ECoG recordings of both spontaneous and induced SWDs in rats with genetic absence epilepsy. We discovered that the duration and intensity of spontaneous SWDs positively correlate with pre-ictal 20-40Hz (β) spectral power and negatively correlate with 4-7Hz (Ø) power. In addition, the output of thalamocortical neurons decreases within the same pre-ictal window of time. In separate experiments we found that the propensity for SWD induction was correlated with pre-ictal β power. These results argue that CTC networks undergo a pre-seizure state transition, possibly due to a functional reorganization of cortical microcircuits, which leads to the generation of absence seizures.

KEYWORDS:

Brain-state; Epilepsy; Networks; Oscillations; Thalamocortical

PMID:
28576554
PMCID:
PMC5607110
DOI:
10.1016/j.jphysparis.2017.05.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center