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Clin Genitourin Cancer. 2017 Dec;15(6):629-634.e8. doi: 10.1016/j.clgc.2017.03.011. Epub 2017 Mar 30.

Tools for Predicting Clinical and Patient-reported Outcomes in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Systematic Review of Prognostic Accuracy and Validity.

Author information

1
Joanna Briggs Institute, University of Adelaide, Adelaide, SA, Australia. Electronic address: jared.campbell@adelaide.edu.au.
2
South Australian Prostate Cancer Clinical Outcomes Collaborative, Adelaide, SA, Australia; Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, SA, Australia; Urology Unit, Repatriation General Hospital, SA Health, Adelaide, SA, Australia; Flinders Centre for Innovation in Cancer, Adelaide, SA, Australia.
3
South Australian Prostate Cancer Clinical Outcomes Collaborative, Adelaide, SA, Australia.
4
Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, SA, Australia.
5
South Australian Prostate Cancer Clinical Outcomes Collaborative, Adelaide, SA, Australia; Centre for Population Health Research, University of South Australia, Adelaide, SA, Australia.
6
Centre for Population Health Research, University of South Australia, Adelaide, SA, Australia.
7
Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Vic, Australia.
8
Department of Radiation Oncology, Alfred Health, Adelaide, SA, Australia.
9
South Australian Prostate Cancer Clinical Outcomes Collaborative, Adelaide, SA, Australia; Adelaide Radiotherapy Centre, Adelaide, SA, Australia.
10
South Australian Prostate Cancer Clinical Outcomes Collaborative, Adelaide, SA, Australia; Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, SA, Australia; Flinders Centre for Innovation in Cancer, Adelaide, SA, Australia; Centre for Population Health Research, University of South Australia, Adelaide, SA, Australia; Discipline of Surgery, University of Adelaide, Adelaide, SA, Australia.

Abstract

Androgen deprivation therapy (ADT) can result in a range of adverse symptoms that reduce patients' quality of life. Careful patient counseling on the likely clinical outcomes and adverse effects is therefore vital. The present systematic review was undertaken to identify and characterize all the tools used for the prediction of clinical and patient-reported outcome measures (PROMs) in patients with prostate cancer undergoing ADT. PubMed and EMBASE were systematically searched from 2007 to 2016. Search terms related to the inclusion criteria were: prostate cancer, clinical outcomes, PROMs, ADT, and prognosis. Titles and abstracts were reviewed to find relevant studies, which were advanced to full-text review. The reference lists were screened for additional studies. The Centre for Evidence Based Medicine critical appraisal of prognostic studies tool was applied. The search strategy identified 8755 studies. Of the 8755 studies, 22 on clinical outcomes were identified. However, no studies of PROMs were found. Nine tools could be used to predict clinical outcomes in treatment-naive patients and 10 in patients with recurrence. The Japan Cancer of the Prostate Risk Assessment (J-CAPRA) nomogram was the best performing and validated tool for the prediction of clinical outcomes in treatment-naive patients, and the Chi and Shamash prognostic indexes have been validated for use in patients with castration-resistant disease in different clinical contexts. Using the J-CAPRA nomogram should help clinicians deliver accurate, evidence-based counseling to patients undergoing primary ADT. A strong need exists for primary studies that derive and validate tools for the prediction of PROMs in patients undergoing ADT under any circumstance because these are currently absent from the literature.

KEYWORDS:

Androgen antagonists; Neoplasm metastasis; Nomograms; Patient-reported outcome measures; Prostatic neoplasms

PMID:
28576416
DOI:
10.1016/j.clgc.2017.03.011
[Indexed for MEDLINE]

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