Format

Send to

Choose Destination
Curr Opin Microbiol. 2017 Apr;36:128-137. doi: 10.1016/j.mib.2017.05.004. Epub 2017 May 30.

Themes and variations in gene regulation by extracytoplasmic function (ECF) sigma factors.

Author information

1
Department of Biochemistry and Molecular Biology, 408 Althouse Laboratory, The Pennsylvania State University, University Park, PA 16802, USA.
2
Department of Biochemistry and Molecular Biology, 408 Althouse Laboratory, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: sea10@psu.edu.

Abstract

The ECF sigma family was identified 23 years ago as a distinct group of σ70-like factors. ECF sigma factors have since emerged as a major form of bacterial signal transduction that can be grouped into over 50 phylogenetically distinct subfamilies. Advances in our understanding of these sigma factors and the signaling pathways governing their activity have elucidated conserved features as well as aspects that have evolved over time. All ECF sigma factors are predicted to share a common streamlined domain structure and mode of promoter interaction. The activity of most ECF sigma factors is controlled by an anti-sigma factor. The nature of the anti-sigma factor and the activating signaling pathways appear to be conserved within ECF families, while considerable diversity exists between different families.

PMID:
28575802
PMCID:
PMC5534382
DOI:
10.1016/j.mib.2017.05.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center