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Cell Stem Cell. 2017 Jun 1;20(6):741-742. doi: 10.1016/j.stem.2017.05.002.

Mitotic Bookmarking: Maintaining the Stem Cell Identity during Mitosis.

Author information

1
The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
2
The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jianlong.wang@mssm.edu.

Abstract

In Cell Reports, Liu et al. (2017) investigate mechanisms for how pluripotent stem cells maintain their identity during cell division. They show that the histone mark H3K27ac and pluripotency transcription factors remain associated with mitotic chromatin in ESCs and during iPSC reprogramming, demonstrating the importance of mitotic bookmarking in pluripotency.

PMID:
28575687
DOI:
10.1016/j.stem.2017.05.002
[Indexed for MEDLINE]
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