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Cell Stem Cell. 2017 Jun 1;20(6):735-736. doi: 10.1016/j.stem.2017.05.003.

Gli-fully Halting the Progression of Fibrosis.

Author information

1
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
2
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: plikus@uci.edu.

Abstract

Activating triggers, selective markers, and the residual regenerative potential of scar-forming myofibroblasts are largely determined by their origin. In this issue of Cell Stem Cell, Schneider et al. report that bone marrow myofibroblasts derive from Gli1+ mesenchymal stromal cells and that a Gli inhibitor targets them for elimination in mice and humans, ameliorating fibrosis.

PMID:
28575684
DOI:
10.1016/j.stem.2017.05.003
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