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Cell. 2017 Jun 1;169(6):985-999. doi: 10.1016/j.cell.2017.05.016.

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Author information

1
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: rnusse@stanford.edu.
2
Hubrecht Institute, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

Abstract

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

KEYWORDS:

Wnt; cancer; development; stem cells; therapy

PMID:
28575679
DOI:
10.1016/j.cell.2017.05.016
[Indexed for MEDLINE]
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