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Chin J Dent Res. 2017;20(2):105-109. doi: 10.3290/j.cjdr.a38275.

Effects of Combining Insulin-like Growth Factor 1 and Platelet-derived Growth Factor on Osteogenesis around 
Dental Implants.



To explore the effects of the combination of insulin-like growth factor 1 (IGF-1) and platelet-derived growth factor (PDGF) on bone formation around dental implants.


A total of 24 adult rabbits were included in this experiment. Titanium machine-polished dental implants were placed in the iliac bones to simulate dental implants in the alveolar bone. The rabbits were randomly divided into four groups; a saline treated control group (NS), an IGF-1 treated group, a PDGF-BB treated group, and a combination of IGF-1 and PDGF-BB treated group. The rabbits were sacrificed after 3, 7, and 10 days, and implants and soft tissues around implants were histologically evaluated.


All of the rabbits began to recover their appetite, move freely and the operation area started detumescence until after the fourth day. H&E staining showed that the granulation tissue formation, multinucleated giant cells, a small amount of calcium salt deposition and bone tissue were observed in the IGF-1 group and the PDGF-BB group. In the IGF-1 + PDGF-BB group, the granulation tissue had turned into fibrous connective tissue, and calcium salt deposit had formed bone tissue. Masson's trichrome staining showed that the IGF-1 group and the PDGF-BB group had more collagen fibre compared with the NS group. In the 
IGF-1 + PDGF-BB group, collagen fibre hyperplasia and repairing fibres appeared earlier than in other groups.


When applying IGF-1 or PDGF-BB alone, either has the effect of accelerating the wound healing in the short term; while in combination, earlier collagen fibre hyperplasia appeared.

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